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Old 22 May 2014, 05:53 PM
A Turtle Named Mack's Avatar
A Turtle Named Mack A Turtle Named Mack is offline
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Icon84 Non-Celiac Gluten Sensitivity May Not Exist

In 2011, Peter Gibson, a professor of gastroenterology at Monash University and director of the GI Unit at The Alfred Hospital in Melbourne, Australia, published a study that found gluten, a protein found in grains like wheat, rye, and barley, to cause gastrointestinal distress in patients without celiac disease, an autoimmune disorder unequivocally triggered by gluten. Double-blinded, randomized, and placebo-controlled, the experiment was one of the strongest pieces of evidence to date that non-celiac gluten sensitivity (NCGS), more commonly known as gluten intolerance, is a genuine condition.

By extension, the study also lent credibility to the meteoric rise of the gluten-free diet. Surveys now show that 30% of Americans would like to eat less gluten, and sales of gluten-free products are estimated to hit $15 billion by 2016 -- that's a 50% jump over 2013's numbers!

But like any meticulous scientist, Gibson wasn't satisfied with his first study. His research turned up no clues to what actually might be causing subjects' adverse reactions to gluten. Moreover, there were many more variables to control! What if some hidden confounder was mucking up the results? He resolved to repeat the trial with a level of rigor lacking in most nutritional research. Subjects would be provided with every single meal for the duration of the trial. Any and all potential dietary triggers for gastrointestinal symptoms would be removed, including lactose (from milk products), certain preservatives like benzoates, propionate, sulfites, and nitrites, and fermentable, poorly absorbed short-chain carbohydrates, also known as FODMAPs. And last, but not least, nine days worth of urine and fecal matter would be collected. With this new study, Gibson wasn't messing around.
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Old 03 June 2014, 12:08 AM
Steve Steve is offline
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Another paper by the same group links gluten to depression in patients without celiac disease, though:
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Old 03 June 2014, 01:59 AM
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Rebochan Rebochan is offline
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Originally Posted by A Turtle Named Mack View Post
And last, but not least, nine days worth of urine and fecal matter would be collected.
Not a pleasant study to participate in!
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Old 03 June 2014, 02:23 PM
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Seaboe Muffinchucker Seaboe Muffinchucker is offline
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Most of the people I know IRL who are fervently anti-gluten do not suffer from either celiac disease nor depression.

I bought a gluten-free bread cookbook and will play around with it, but it seems that if bread gives you trouble, you might try making it from scratch before you declare gluten to be the culprit. And by scratch, I do not mean a bread machine mix. In the bread machine, fine (although what fun is that?), but the mixes are just as likely to have the FODMAPs as store-bought bread is.

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